The mother institution of society, N.M.D Arts and Commerce College ventured to start a Science faculty in its own fold in 1963 . The popularity of the faculty inspired the management of the Society to go ahead with the plan of setting up an independent Science College in Gondia. The founder president of the GES Late Manoharbhai patel along with his companion Late Kashiramji Dhote with their best endeavor to set up Dhote Bandhu Science College in 1969. Since then the college is marching on the path of progress and prosperity. In 1999, at the flag end of last century the management felt a dire need of post graduation courses in the faculty of Science as n such provision was available in the whole district.
Hence the college started post graduation courses in three subjects i.e. Chemistry , Microbiology , and Computer Science in the cadmic session 2003-04 two more post graduate subjects physics and botany were introduced. In 2004, college underwent NAAC accreditation and acquired B+ grade. In 2006, recognised as LEAD college by RTM Nagpur University. In 2007-08, need based certificate/ Diploma courses were stared under UGC scheme.